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Once a person has developed asthma (or has been 'sensitised'), any further exposure to the substance can produce the same reaction. `Sen' notice - sensitiser. The substance can cause a specific immune response in some people. An affected individual may subsequently react to exposure to minute levels of that substance. These Exposure Standards are guides to be used in the control of occupational health hazards.
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1, 1A, or 1B and/or an entry in the Candidate list. Broad agreement: comes from industry data where a majority of data submitters agree the substance is a respiratory sensitiser. 2021-04-01 A substance that will induce an allergic response following skin contact. The definition for "skin sensitizer" is equivalent to "contact sensitizer". Previous: Skin Irritation Next: Solid.
Explosive . An explosive substance or mixture is a solid or liquid substance or mixture of substances which is in itself capable by chemical reaction of producing gas at such a temperature and pressure and at such a speed as to cause damage to the surroundings.
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Observations relating to hyperplasia of urinary bladder epithelium in. FDA/CDC, Center for Food Safety and Applied Nutrition, Food and Drug Administration, U.S. · Department ATBC is not a sensitiser in the guinea pig maximisation test. The intended primary use is in PVC (films, tubes, bottles, sealings, etc.) total of 8 mg g(-1) of 16 PAHs, was sieved and incubated in bottles for 45 days. The present study examined various potential growth-enhancing substances for Disperse Yellow 3 each contain at least one impurity acting as a sensitiser.
2021-04-28T01:56:43Z https://lup.lub.lu.se/oai oai:lup.lub.lu
In addition, any newly synthesised substance or intermediate substance analogous to those listed above or to substances with the R42 risk phrase, or H334 or H335 hazard statements (for example, a new substance containing the isocyanate group) should be regarded as a potential sensitiser, until there is substantive evidence to the contrary. For substances which produce signs of immunological contact urticaria but which do not fulfil the criteria as a respiratory sensitiser, consideration shall be given to classification as a skin sensitiser. Context Ref. Annex I, Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008, 32008R1272/EN respiratory sensitiser (a cause of asthma) and labelling with R42 C1: AZODICARBONAMIDE substances of biological origin, and of solder fume. Terminology and toxicological mechanisms The varying and sometimes overlapping definitions available for key terms, such as irritant, though some substances, such as chrome salts, can act as both irritants and sensitisers. Nor is a skin sensitiser necessarily also a respiratory sensitiser, because their respective allergic mechanisms are also quite different. However, a few substances, such as rosin, are capable of this double allergenic role. classified as a skin sensitiser (H317 ‘may cause an allergic skin reaction’) based on animal and human data presented in the dossier.
The purpose of the harmonised criteria for classification of respiratory and skin sensitisers is
sensitiser - Dictionary definition and meaning for word sensitiser Definition (noun) (chemistry) a substance other than a catalyst that facilitates the start of a catalytic reaction
According to Anton C. De Groot’s book Patch Testing, more than 4,300 substances are identified as contact allergens, which are usually small molecules. Epidemiological studies published in the Journal of Dermatology (in 2016) and Contact Dermatitis (2019) suggest that the prevalence toward developing a skin sensitization or positive allergic contact dermatitis (ACD) in the global population
Definitions of sensitiser.
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There is general agreement on 74 the key biological events underlying skin sensitisation.
2021-04-01 · Consideration of criteria required for assignment of a (skin) sensitiser a substance of very high concern (SVHC) under the REACH regulation. Regul Toxicol Pharmacol. 2014; 69(3):524-8 (ISSN: 1096-0295) Basketter D; Kimber I
Bottled gas is a term used for substances which are gaseous at standard temperature and pressure (STP) and have been compressed and stored in carbon steel, stainless steel, aluminum, or composite bottles known as gas cylinders
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B C1 REGULATION EC No 1907/2006 OF THE - EUR-Lex
Which two tasks below would you class as manual handling? (Choose 2 answers) a. The packaging of a substance has the word 'SENSITISER' on it.
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B C1 REGULATION EC No 1907/2006 OF THE - EUR-Lex
Possible systemic effects. Respiratory sensitising (Sr) – Recognised respiratory sensitiser: comes from a harmonised C&L classifying the substance as Resp. Sens. 1, 1A, or 1B and/or an entry in the Candidate list. Broad agreement: comes from industry data where a majority of data submitters agree the substance is a respiratory sensitiser. substance use disorder – a condition in which the use of substances leads to clinically and functionally significant impairment or distress tolerance – the diminishing effect of a drug resulting from repeated administration at a given dose Consideration of criteria required for assignment of a (skin) sensitiser a substance of very high concern (SVHC) under the REACH regulation May 2014 Regulatory Toxicology and Pharmacology 69(3) Read more about common allergenic substances by following the links below.